12 January 2019

Scientists have developed a new test that scans the shapes of tumour cells to pick out women with especially aggressive ovarian cancer, so treatment can be tailored to their needs.

The Institute of Cancer Research created an artificial intelligence (AI) tool that looks for clusters of cells within tumours with misshapen nuclei – the control centres within each cell.

Misshapen nuclei was an indication that the DNA of cancer cells had become unstable, which could help doctors to select the best treatment for each patient in future.

Cancers with misshapen cell nuclei had hidden weaknesses in their ability to repair DNA, which could make them susceptible to PARP inhibitor drugs or platinum chemotherapy.Further research is needed into this exciting possibility for more personalised treatment of ovarian cancer.

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